Diana Whitaker-Menezes Selected Research

Caveolin 1

1/2018	Metformin Effects on Metabolic Coupling and Tumor Growth in Oral Cavity Squamous Cell Carcinoma Coinjection Xenografts.
1/2017	Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer.
11/2012	Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells.
11/2012	Ketone body utilization drives tumor growth and metastasis.
7/2012	Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug.
5/2012	Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration.
12/2011	Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
12/2011	Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection.
7/2011	Scleroderma-like properties of skin from caveolin-1-deficient mice: implications for new treatment strategies in patients with fibrosis and systemic sclerosis.
6/2011	Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis.

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Diana Whitaker-Menezes Research Topics

Disease

56	Neoplasms (Cancer) 01/2022 - 02/2009
27	Breast Neoplasms (Breast Cancer) 01/2017 - 03/2009
15	Neoplasm Metastasis (Metastasis) 11/2012 - 03/2007
7	Inflammation (Inflammations) 06/2017 - 06/2011
7	Hypoxia (Hypoxemia) 12/2016 - 09/2010
7	Mitochondrial Diseases (Mitochondrial Disease) 05/2013 - 08/2010
5	Carcinogenesis 02/2013 - 11/2009
4	Carcinoma (Carcinomatosis) 01/2022 - 12/2016
4	Squamous Cell Carcinoma of Head and Neck 01/2019 - 01/2018
4	Starvation 11/2012 - 12/2011
4	Lymphatic Metastasis 04/2012 - 08/2010
3	Graft vs Host Disease (Graft-Versus-Host Disease) 10/2004 - 09/2002
2	Uremia 01/2021 - 06/2017
2	Head and Neck Neoplasms (Head and Neck Cancer) 01/2018 - 05/2013
2	Disease Progression 01/2018 - 01/2007
2	Hypertrophy 05/2013 - 06/2012
2	Melanoma (Melanoma, Malignant) 05/2012 - 10/2010
1	Lymphoma (Lymphomas) 01/2021
1	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 01/2021
1	Chondrosarcoma 12/2020
1	Mouth Neoplasms (Oral Cancer) 01/2018
1	Chronic Kidney Failure (Chronic Renal Failure) 06/2017
1	Hodgkin Disease (Hodgkin's Disease) 01/2017
1	Triple Negative Breast Neoplasms 01/2017
1	Ductal Carcinoma 01/2017
1	Premature Aging 03/2013
1	Ovarian Neoplasms (Ovarian Cancer) 11/2012

Drug/Important Bio-Agent (IBA)

24	Lactic Acid (Lactate)FDA LinkGeneric 01/2017 - 06/2010
17	Caveolin 1IBA 01/2018 - 03/2009
15	Biomarkers (Surrogate Marker)IBA 12/2020 - 05/2010
13	Proteins (Proteins, Gene)FDA Link 01/2017 - 01/2007
11	KetonesIBA 05/2013 - 09/2010
9	AntioxidantsIBA 01/2017 - 09/2010
9	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 12/2012 - 08/2011
7	Tamoxifen FDA LinkGeneric 02/2011 - 03/2009
6	EnzymesIBA 12/2016 - 02/2011
6	Ketone BodiesIBA 05/2013 - 04/2012
5	CarcinogensIBA 01/2021 - 09/2010
5	CytokinesIBA 01/2021 - 09/2003
5	Metformin (Glucophage)FDA LinkGeneric 01/2018 - 12/2011
5	Pharmaceutical PreparationsIBA 01/2018 - 06/2010
5	Adenosine Triphosphate (ATP)IBA 12/2016 - 12/2009
4	Glutamine (L-Glutamine)FDA Link 12/2016 - 09/2010
4	Chloroquine (Aralen)FDA LinkGeneric 12/2012 - 06/2010
3	LigandsIBA 02/2013 - 11/2009
2	Interleukin-6 (Interleukin 6)IBA 01/2021 - 02/2013
2	SmokeIBA 01/2019 - 03/2013
2	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 01/2018 - 01/2018
2	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2017 - 09/2010
2	Cysteine (L-Cysteine)FDA Link 06/2017 - 11/2012
2	Antineoplastic Agents (Antineoplastics)IBA 05/2013 - 12/2012
2	AntibodiesIBA 12/2012 - 11/2012
2	Milk Proteins (Milk Protein)IBA 11/2012 - 02/2009
2	Transcription Factors (Transcription Factor)IBA 09/2012 - 09/2012
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 09/2012 - 12/2011
2	Sirolimus (Rapamycin)FDA Link 07/2012 - 11/2010
2	CaveolinsIBA 07/2012 - 03/2011
2	Caveolin 3IBA 03/2011 - 02/2009
2	SolutionsIBA 11/2010 - 09/2010
2	Messenger RNA (mRNA)IBA 10/2010 - 11/2003
2	Pyruvic Acid (Pyruvate)IBA 09/2010 - 06/2010
1	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2022
1	1- cyclopropyl- 4- (4- ((5- methyl- 3- (3- (4- (trifluoromethoxy)phenyl)- 1,2,4- oxadiazol- 5- yl)- 1H- pyrazol- 1- yl)methyl)pyridin- 2- yl)piperazineIBA 01/2022
1	Calcineurin InhibitorsIBA 01/2021
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 12/2020
1	4-Nitroquinoline-1-oxide (4 Nitroquinoline 1 oxide)IBA 01/2018
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2017
1	Estrogen ReceptorsIBA 01/2017
1	Acetylcysteine (Siran)FDA LinkGeneric 01/2017
1	Coloring Agents (Dyes)IBA 01/2017
1	human ERBB2 proteinIBA 01/2017
1	Hydroxyl RadicalIBA 01/2017
1	Phosphotransferases (Kinase)IBA 12/2016
1	Lactate Dehydrogenase 5IBA 12/2016
1	Glucose (Dextrose)FDA LinkGeneric 12/2016
1	FructoseIBA 12/2016
1	Fatty Acids (Saturated Fatty Acids)IBA 05/2013
1	DNA (Deoxyribonucleic Acid)IBA 03/2013
1	MutagensIBA 03/2013
1	Interleukin-8 (Interleukin 8)IBA 02/2013
1	CollagenIBA 02/2013
1	Antimalarials (Antimalarial Agents)IBA 12/2012
1	tempolIBA 12/2012
1	BRCA1 ProteinIBA 12/2012
1	LipidsIBA 12/2012
1	PoisonsIBA 11/2012
1	Caseins (Casein)FDA Link 11/2012
1	InterferonsIBA 11/2012
1	Butyrates (Butyrate)IBA 11/2012
1	palbociclibIBA 10/2012
1	Cyclin-Dependent Kinase Inhibitor p16IBA 10/2012
1	Fibronectins (Fibronectin)IBA 09/2012
1	Protein Isoforms (Isoforms)IBA 09/2012
1	Cyclin D1IBA 09/2012
1	NF-kappa B (NF-kB)IBA 08/2012

Therapy/Procedure

21	Therapeutics 01/2018 - 02/2009
2	Injections 01/2022 - 02/2013
1	Organ Transplantation 01/2021
1	Drug Therapy (Chemotherapy) 12/2020
1	Neoadjuvant Therapy 01/2017